In this Aug. 29, 2018, file photo, a customer tries a free sample of a pain cream that contains cannabidiol (CBD) for her arthritis at Minnesota Hempdropz in Maplewood, Minn. Mainstream retailers are leaping into the world of products like skin creams and oils that tout such benefits as reducing anxiety and helping you sleep. The key ingredient is CBD, or cannabidiol, a compound derived from hemp and marijuana that doesn’t cause a high. (Jean Pieri/Pioneer Press via AP, File)